IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.

Abstract

Recombinant human interleukin 11 (rhIL-11) is a pleiotropic cytokine that stimulates bone marrow stem cells to proliferate and decreases intestinal mucosal injury produced by cytoablative drugs and radiation in animals. The effects of rhIL-11 were studied in a hamster model of oral mucositis and in two rat models of inflammatory bowel disease (IBD). Oral mucositis was induced in male Golden Syrian hamsters with 5-fluorouracil 60 mg/kg intraperitoneal, days 0 and 2. Peak mucositis occurred by day 10 in vehicle treated animals. rhIL-11, given twice daily subcutaneously, decreased the mucositis in a dose-dependent manner and increased animal survival at all doses tested. In two models of IBD, the acetic acid-induced acute colonic injury model in Sprague-Dawley rats and the transgenic Fischer 344 rats expressing human HLA-B27 and beta 2-microglobulin, rhIL-11 decreased the gross and microscopic damage in the colons of these animals. These data suggest that rhIL-11 exerts effects on the gastrointestinal mucosa which ameliorate responses to injurious stimuli.

• Authors: J C Keith Jr, L Albert, S T Sonis, C J Pfeiffer, R G Schaub
• Journal: Stem cells (Dayton, Ohio) (Stem Cells) Vol. 12 Suppl 1 Pg. 79-89; discussion 89-90 ( 1994) ISSN: 1066-5099 [Print] England
• PMID: 7696971 (Publication Type: Journal Article)

Chemical References

• Acetates
• HLA-B27 Antigen
• Interleukin-11
• Recombinant Proteins
• beta 2-Microglobulin
• Acetic Acid
• Fluorouracil

Topics

• Acetates (toxicity)
• Acetic Acid
• Animals
• Animals, Genetically Modified
• Colitis (chemically induced, drug therapy, pathology)
• Cricetinae
• Disease Models, Animal
• Fluorouracil (toxicity)
• Gastric Mucosa (drug effects, injuries)
• HLA-B27 Antigen (genetics)
• Humans
• Inflammatory Bowel Diseases (drug therapy, genetics, pathology)
• Interleukin-11 (pharmacology, physiology)
• Intestinal Mucosa (drug effects, injuries)
• Male
• Mesocricetus
• Mouth Mucosa
• Rats
• Rats, Inbred F344
• Rats, Sprague-Dawley
• Recombinant Proteins (pharmacology)
• Stomatitis (chemically induced, drug therapy, pathology)
• beta 2-Microglobulin (genetics)