[The anti-arrhythmic activity of quinuclidine derivatives].

Abstract

Experiments on conscious rabbits have shown that the quinuclidine bicarphene displays a sufficiently profound antiarrhythmic activity. The agent, 1.0 mg/kg, prevents and abolishes arrhythmias induced by calcium chloride, strophanthin, and epinephrine and fails to affect the cardiac arrhythmias caused by aconitine and barium chloride. Higher bicarphene doses (1.5-2.0 mg/kg) results in severe bradycardia in intact rabbits, slower atrioventricular conduction. It is suggested that the antiarrhythmic activity of bicarphene is associated with its effects on cardiomyocytic membranous Ca2+ transport.

• Authors: A S Svistov, V I Skorobogatov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Sep-Oct Vol. 57 Issue 5 Pg. 20-1 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Izuchenie antiaritmicheskoĭ aktivnosti proizvodnykh khinuklidina.
• PMID: 7696896 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Quinuclidines
• bicarphene

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology, therapeutic use)
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Electrocardiography (drug effects)
• Heart Rate (drug effects)
• Male
• Quinuclidines (pharmacology, therapeutic use)
• Rabbits