[The hemodynamic and renal effects of synthetic atriopeptides in waking rats under conditions of volumetric loading].

Abstract

Changes in mean blood pressure (MBP), heart rate (HR), diuresis, natriuresis and kaliuresis, which had been evoked by intravenous bolus administration of the synthetic atrial natriuretic peptides (ANP) ANP (99-126), ANP (103-126), ANP (103-125), and ANP (103-123) in doses of 10 and 60 micrograms/kg each, were studied during 2% body weight volume expansion by intraarterial injections of 0.9% NaCl in awake rats. All the ANP analogues were indicated to decrease MBP and induce differential changes in HR. All the ANP analogues, except ANP (103-123), increased diuresis and natriuresis in the first 30 min of the experiment.

• Authors: A N Murashev, M D Smetanina, S A Davydova, Zh D Bespalova, O S Medvedev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Sep-Oct Vol. 57 Issue 5 Pg. 18-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Gemodinamicheskie i pochechnye éffekty sinteticheskikh atriopeptidov u bodrstvuiushchikh krys v usloviiakh ob''emnoĭ nagruzki.
• PMID: 7696895 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Peptide Fragments
• Sodium Chloride
• Atrial Natriuretic Factor

Topics

• Animals
• Atrial Natriuretic Factor (pharmacology)
• Blood Volume (drug effects)
• Diuresis (drug effects)
• Dose-Response Relationship, Drug
• Hemodynamics (drug effects)
• Kidney (drug effects, physiology)
• Male
• Peptide Fragments (pharmacology)
• Rats
• Sodium Chloride (administration & dosage)
• Statistics, Nonparametric
• Time Factors
• Wakefulness (drug effects, physiology)