[The spectrum of the anticonvulsant action of morfolid ].

Abstract

The albino experiments have shown that morpholide has an anticonvulsant effect in electroshock-, corazole-, thiosemicarbazide-, bicuculline-, strychnine-, arecoline-, nicotine-, tremorine-induced convulsions and tremors. The agent has a wider range of pharmacological effects than phenobarbital. There is a higher anticonvulsant effect of morpholide combined with phenobarbital, hexamidine and diazepam. It is suggested that GABA-ergic mechanisms contribute to the anticonvulsant action of morpholide.

• Authors: E V Rudometova, N A Popova, V E Kolla
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Sep-Oct Vol. 57 Issue 5 Pg. 11-3 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: O spektre protivosudorozhnogo deĭstviia morfolida.
• PMID: 7696892 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Morpholines
• Phenobarbital

Topics

• Animals
• Anticonvulsants (therapeutic use, toxicity)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Female
• Lethal Dose 50
• Male
• Mice
• Morpholines (therapeutic use, toxicity)
• Phenobarbital (therapeutic use, toxicity)
• Seizures (drug therapy, etiology)
• Tremor (chemically induced, drug therapy)