[Cefoperazone in the prevention and treatment of experimental plague caused by typical and fraction-free pathogen strains in white mice].

Abstract

The high susceptibility of the plague microbe to cefoperazone (MIC of 0.1-0.25 microgram/ml) did not depend on the causative agent ability to produce fraction I. Cefoperazone, a 3rd generation cephalosporin, was highly active in the treatment of experimental plague caused by the plague microbe strain typical in the antigen composition: the drug daily dose of 250-500 mg/kg provided an 80-100 percent survival of the albino mice. The efficacy of cefoperazone lowered when the infection was caused by the strain defective in the capsule antigen. The use of the antibiotic for more prolonged periods provided better results of the etiotropic therapy.

• Authors: V V Pasiukov, I V Ryzhko, R I Tsuraeva, E D Samokhodkina, N V Roshchina
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 39 Issue 8 Pg. 37-40 (Aug 1994) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Tsefoperazon v profilaktike i lechenii éksperimental'noĭ chumy belykh mysheĭ, vyzvannoĭ tipichnym i besfraktionnymi shtammami vozbuditelia.
• PMID: 7695439 (Publication Type: Journal Article)

Chemical References

• Antigens, Bacterial
• Cefoperazone

Topics

• Animals
• Antigens, Bacterial (analysis)
• Bacterial Capsules (immunology)
• Cefoperazone (therapeutic use)
• Mice
• Microbial Sensitivity Tests
• Plague (drug therapy, prevention & control)
• Survival Rate
• Yersinia pestis (drug effects, immunology)