The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro.

Abstract

Five spermicides including nonoxynol-9 were assessed under in-vitro conditions, for their inhibitory activity against two viruses capable of spread by sexual intercourse, herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1. A further eight commercially-available spermicidal preparations containing varying concentrations of either nonoxynol-9 or nonoxynol-11 were also assessed for activity against HSV-2. All spermicides and spermicidal preparations tested showed inhibitory activity against both viruses over periods of time ranging from 30 sec to 5 min. This activity was dependent on the concentration of spermicide to which the viruses were exposed.

• Authors: R Jennings, A Clegg
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 32 Issue 1 Pg. 71-82 (Jul 1993) ISSN: 0305-7453 [Print] England
• PMID: 7693643 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Benzalkonium Compounds
• Spermatocidal Agents
• Dioctyl Sulfosuccinic Acid
• Nonoxynol
• Polyethylene Glycols
• menfegol

Topics

• Antiviral Agents (pharmacology)
• Benzalkonium Compounds (pharmacology)
• Dioctyl Sulfosuccinic Acid (pharmacology)
• HIV-1 (drug effects, physiology)
• Herpesvirus 2, Human (drug effects, physiology)
• Humans
• Nonoxynol (pharmacology)
• Polyethylene Glycols (pharmacology)
• Spermatocidal Agents (pharmacology)
• Virus Replication (drug effects)