Abstract |
1. The effect of different stressful stimuli on the function of the GABAA- ionophore receptor complex was evaluated by measuring the binding of 35S-TBPS to the chloride channel associated recognition sites. 2. Foot- shock stress enhanced 35S-TBPS binding in membrane preparation from rat cerebral cortex. The effect of foot- shock on 35S-TBPS binding was mimicked by the anxiogenic and proconvulsant beta-carboline FG 7142 and antagonized by anxiolytic benzodiazepines and by the novel anxiolytic and anticonvulsant beta-carboline, abecarnil. 3. A brief exposure of rats to CO2 inhalation produced, like foot- shock and FG 7142, a marked increase of 35S-TBPS binding in the cerebral cortex, cerebellum and hippocampus. The effect of CO2 inhalation was maximal 10 min after treatment and return to control value in 2 hours. Previous administration of anxiolytic drugs ( alprazolam and abecarnil) completely prevented the CO2 inhalation-induced increase of 35S-TBPS binding. 4. All together these data strongly suggest that carbon dioxide inhalation, like stress and anxiogenic drugs, decreases the function of the GABAA receptor complex.
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Authors | A Concas, E Sanna, T Cuccheddu, M P Mascia, G Santoro, E Maciocco, G Biggio |
Journal | Progress in neuro-psychopharmacology & biological psychiatry
(Prog Neuropsychopharmacol Biol Psychiatry)
Vol. 17
Issue 4
Pg. 651-61
(Jul 1993)
ISSN: 0278-5846 [Print] England |
PMID | 7689736
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Anxiety Agents
- Bridged Bicyclo Compounds
- Bridged Bicyclo Compounds, Heterocyclic
- Carbolines
- Chloride Channels
- Ion Channels
- Membrane Proteins
- Receptors, GABA-A
- Benzodiazepines
- Carbon Dioxide
- FG 7142
- tert-butylbicyclophosphorothionate
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Topics |
- Administration, Inhalation
- Animals
- Anti-Anxiety Agents
(pharmacology)
- Anxiety
(chemically induced, metabolism)
- Benzodiazepines
- Brain Chemistry
(drug effects, physiology)
- Bridged Bicyclo Compounds
(metabolism)
- Bridged Bicyclo Compounds, Heterocyclic
- Carbolines
(pharmacology)
- Carbon Dioxide
(administration & dosage, pharmacology)
- Cerebellum
(drug effects, metabolism)
- Cerebral Cortex
(drug effects, metabolism)
- Chloride Channels
- Electroshock
- Hippocampus
(drug effects, metabolism)
- Ion Channels
(drug effects, metabolism)
- Male
- Membrane Proteins
(drug effects, metabolism)
- Rats
- Rats, Sprague-Dawley
- Receptors, GABA-A
(drug effects, metabolism)
- Stress, Psychological
(metabolism)
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