Abstract |
In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.
|
Authors | P M Steijlen, D O Reifenschweiler, F C Ramaekers, G N van Muijen, R Happle, M Link, D J Ruiter, P C van de Kerkhof |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 285
Issue 4
Pg. 221-6
( 1993)
ISSN: 0340-3696 [Print] Germany |
PMID | 7688204
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
|
Chemical References |
- Antibodies, Monoclonal
- Keratins
- Isotretinoin
|
Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Antibodies, Monoclonal
- Darier Disease
(drug therapy)
- Double-Blind Method
- Female
- Humans
- Ichthyosis, Lamellar
(drug therapy)
- Immunoenzyme Techniques
- Isotretinoin
(administration & dosage)
- Keratins
(analysis)
- Male
|