Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid. A clinical and immunohistochemical study.

Abstract

In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.

• Authors: P M Steijlen, D O Reifenschweiler, F C Ramaekers, G N van Muijen, R Happle, M Link, D J Ruiter, P C van de Kerkhof
• Journal: Archives of dermatological research (Arch Dermatol Res) Vol. 285 Issue 4 Pg. 221-6 ( 1993) ISSN: 0340-3696 [Print] Germany
• PMID: 7688204 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Keratins
• Isotretinoin

Topics

• Administration, Cutaneous
• Adolescent
• Adult
• Antibodies, Monoclonal
• Darier Disease (drug therapy)
• Double-Blind Method
• Female
• Humans
• Ichthyosis, Lamellar (drug therapy)
• Immunoenzyme Techniques
• Isotretinoin (administration & dosage)
• Keratins (analysis)
• Male