[Recombinant G-CSF and the interstitial pneumonia during MACOP-B therapy in two cases of non-Hodgkin's lymphoma].

Abstract

Two cases of non-Hodgkin's lymphoma suffered from acute respiratory failure. Both patients were treated with MACOP-B therapy, and received recombinant granulocyte-colony stimulating factor (rG-CSF) during the myelosuppression. They had fever and severe hypoxemia several days after 11 and 12-week's treatment, respectively. The chest X-ray films revealed diffuse fine granular shadows in bilateral lung fields. The number of white blood cells had rapidly increased when the shadows appeared. These cases suggested the possibility that rG-CSF, or the rapid increase of white blood cells, might induce interstitial pneumonia.

• Authors: Y Okubo, K Nakazawa
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 34 Issue 4 Pg. 473-7 (Apr 1993) ISSN: 0485-1439 [Print] Japan
• PMID: 7685433 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Recombinant Proteins
• Bleomycin
• Granulocyte Colony-Stimulating Factor
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Leucovorin
• Prednisone
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Granulocyte Colony-Stimulating Factor (adverse effects)
• Humans
• Leucovorin (administration & dosage)
• Leukocytosis (chemically induced)
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Prednisone (administration & dosage)
• Pulmonary Fibrosis (chemically induced)
• Recombinant Proteins (adverse effects)
• Vincristine (administration & dosage)