Abstract |
Expression of the CD15 antigen, which is one of the adhesion molecules, was studied immunohistochemically to investigate the mechanism of intrahepatic metastasis in 56 hepatocellular carcinomas (HCC). Twenty-nine percent (16 of 56) of the HCC expressed CD15. No noncancerous hepatocytes expressed CD15. CD15-positive HCC had histologic intrahepatic metastasis more often than did CD15-negative HCC; the difference was statistically significant (P < 0.02). The survival rate of patients with CD15-negative HCC was better than that of patients with CD15-positive HCC, although the difference was not statistically significant. The authors speculate that there is a relationship between the expression of CD15 and intrahepatic metastasis in HCC.
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Authors | A Torii, A Nakayama, A Harada, A Nakao, T Nonami, J Sakamoto, T Watanabe, M Ito, H Takagi |
Journal | Cancer
(Cancer)
Vol. 71
Issue 12
Pg. 3864-7
(Jun 15 1993)
ISSN: 0008-543X [Print] United States |
PMID | 7685236
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Biomarkers, Tumor
- Lewis X Antigen
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Topics |
- Antigens, CD
(analysis, genetics)
- Antigens, Differentiation, Myelomonocytic
(analysis, genetics)
- Biomarkers, Tumor
(analysis, genetics)
- Carcinoma, Hepatocellular
(genetics, immunology, pathology, secondary, surgery)
- Cell Membrane
(immunology)
- Female
- Gene Expression
- Hepatectomy
(methods)
- Humans
- Lewis X Antigen
- Liver Neoplasms
(genetics, immunology, pathology, secondary, surgery)
- Male
- Middle Aged
- Staining and Labeling
- Survival Rate
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