Skin anti-inflammatory activity of apigenin-7-glucoside in rats.

Abstract

The effect of apigenin-7-glucoside on skin inflammation induced by different generators of reactive oxygen species and free radicals was studied. Skin inflammation in rats was induced by intradermal injection of glucose-oxidase (hydrogen peroxide), xanthine-oxidase/hypoxanthine (superoxide anion radical), and cumene hydroperoxide (peroxyl radical). Subsequent intradermal application of liposomal apigenin-7-glucoside inhibited in a dose dependent manner skin inflammation caused by xanthine-oxidase and cumene hydroperoxide. Glucose-oxidase induced dermatitis was not significantly inhibited. The results are in good agreement with the in-vitro superoxide anion radical and peroxyl radical scavenging properties of apigenin and indicate that its antioxidant properties contribute to the anti-inflammatory effect in this model system.

• Authors: J Fuchs, R Milbradt
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 43 Issue 3 Pg. 370-2 (Mar 1993) ISSN: 0004-4172 [Print] Germany
• PMID: 7683883 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antioxidants
• Benzene Derivatives
• Flavonoids
• Liposomes
• Prostaglandins
• apigetrin
• Apigenin
• Glucose Oxidase
• Xanthine Oxidase
• cumene hydroperoxide

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Antioxidants (pharmacology)
• Apigenin
• Benzene Derivatives (pharmacology)
• Dermatitis, Contact (drug therapy, metabolism, pathology)
• Flavonoids (pharmacology)
• Glucose Oxidase (pharmacology)
• Histamine Release (drug effects)
• Liposomes
• Male
• Prostaglandins (biosynthesis)
• Rats
• Rats, Wistar
• Xanthine Oxidase (pharmacology)