[The role of M-VAC polychemotherapy in the treatment of advanced urothelial carcinoma of the bladder].

Abstract

Over the last seven years, M-VAC combination chemotherapy has been used for: the treatment of transitional cell carcinoma with metastases (palliative indication) or to reduce operable T4a tumours (inductive, initial or preliminary indication), or before or after t for bladder cancers (neoadjuvant and adjuvant indications). The authors present their experience of 17 cases of stage T4a transitional cell carcinoma transformed into an operable stage by M-VAC. Those patients with regression of the tumour to a non-invasive stage at operation (patients with a good response) had a good prognosis. In contrast those patients with residual invasive tumour all died from their disease. A prospective comparative study was performed between total cystectomy alone and cystectomy completed by adjuvant M-VAC in patients with a worrying histology. This study was based on 49 cases up until December 1990. A significant improvement in the prognosis was observed in patients receiving adjuvant M-VAC. The recurrence-free survival was considerably prolonged in this second group (study suspended in November 1992). When metastases developed, palliative M-VAC only rarely prolonged survival.

• Authors: M Stöckle, W Meyenburg, S Wellek, G Voges, U Gertenbach, J W Thüroff, C Huber, R Hohenfellner
• Journal: Annales d'urologie (Ann Urol (Paris)) Vol. 27 Issue 1 Pg. 51-7 ( 1993) ISSN: 0003-4401 [Print] France
• Vernacular Title: Rôle de la polychimiothérapie M-VAC dans le traitement du carcinome urothélial avancé de la vessie.
• PMID: 7682388 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Epirubicin
• Vinblastine
• Doxorubicin
• Cisplatin
• Methotrexate

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma in Situ (drug therapy, pathology, surgery)
• Carcinoma, Transitional Cell (drug therapy, pathology, secondary, surgery)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Cystectomy
• Doxorubicin (administration & dosage)
• Epirubicin (administration & dosage)
• Female
• Humans
• Lymphatic Metastasis
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Palliative Care
• Remission Induction
• Urinary Bladder Neoplasms (drug therapy, pathology, surgery)
• Vinblastine (administration & dosage)