[Serodiagnosis of hepatitis C by a recombinant hepatitis C virus protein].

Abstract

Anti-HCV prevalence was high in chronic non-A, non-B liver disease. Anti-C100-3 was detected frequently in each category of chronic non-A, non-B liver disease. Antibody to HCV core protein was detected more frequently in 95% with high titers. A significant correlation was observed between the occurrence of high titers of antibody to HCV core and serum HCV RNA positivity. In patients negative by the anti-C100-3 assay, 69% were anti-HCV-positive by the second-generation enzyme-linked immunosorbent assay and also positive by the reverse transcription-polymerase chain reaction. Thus, HCV is a major causative agent of chronic non-A, non-B hepatitis in Japan.

• Authors: N Hayashi, N Yuki, A Kasahara, H Fusamoto, T Kamada
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 51 Issue 2 Pg. 329-33 (Feb 1993) ISSN: 0047-1852 [Print] Japan
• PMID: 7681883 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antigens, Viral
• C100 protein, hepatitis C virus
• Hepatitis Antibodies
• Hepatitis C Antibodies
• RNA, Viral
• Recombinant Proteins
• Viral Core Proteins
• Viral Nonstructural Proteins
• Viral Proteins
• nucleocapsid protein, Hepatitis C virus

Topics

• Antigens, Viral
• Genome, Viral
• Hepacivirus (genetics, isolation & purification)
• Hepatitis Antibodies (analysis)
• Hepatitis C (diagnosis, microbiology)
• Hepatitis C Antibodies
• Humans
• Polymerase Chain Reaction
• RNA, Viral (analysis)
• Recombinant Proteins (immunology)
• Serologic Tests (methods)
• Viral Core Proteins (immunology)
• Viral Nonstructural Proteins (immunology)
• Viral Proteins (immunology)