In vivo angiogenesis by platelet-derived wound-healing formula in injured spinal cord.

Abstract

In vivo angiogenesis was investigated using platelet-derived wound-healing formula (PDWHF) in the injured cat spinal cord. Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks. Selection of PDWHF-Hydron or Hydron was double blinded. The PDWHF-Hydron group showed notable neovascularization as well as dilation around the injury site, and this was statistically significant when compared to the control group. PDWHF seems to play a role in the healing processes of spinal cord injury and may have important interactions with other growth factors and in particular neurogenic growth factor.

• Authors: Y Hiraizumi, E E Transfeldt, N Kawahara, J H Sung, D Knighton, V D Fiegel
• Journal: Brain research bulletin (Brain Res Bull) Vol. 30 Issue 3-4 Pg. 353-7 ( 1993) ISSN: 0361-9230 [Print] United States
• PMID: 7681352 (Publication Type: Journal Article)

Chemical References

• CT-102 activated platelet supernatant
• Complex Mixtures
• Growth Substances

Topics

• Animals
• Blood Platelets
• Cats
• Complex Mixtures
• Double-Blind Method
• Growth Substances (therapeutic use)
• Neovascularization, Pathologic (chemically induced)
• Spinal Cord Injuries (drug therapy, physiopathology)
• Wound Healing