Field safety and efficacy of in ovo administration of HVT + SB-1 bivalent Marek's disease vaccine in commercial broilers.

The field safety and efficacy of a bivalent Marek's disease (MD) vaccine (herpesvirus of turkeys + strain SB-1) administered in ovo were evaluated. The vaccine was administered to commercial broiler chicken eggs using Embrex's INOVOJECT automated egg-injection system. Comparisons were made with a conventional method of vaccination, in which the vaccine was administered subcutaneously to chicks at hatching. In ovo administration of the vaccine at day 17.5-18.5 of incubation significantly reduced the number of culled chicks, early mortality, and overall mortality during the grow-out period compared with conventional vaccination. However, hatchability was significantly lower in in ovo-treated chicks. Overall livability and feed efficiency were higher in the in ovo-treated chicks than in conventionally vaccinated chicks. Total field-caused condemnations and condemnations due to airsacculitis and septicemia/toxemia were also lower in the in ovo-vaccinated chicks. No difference in the leukosis (MD) condemnation rate was observed between the two treatment groups. In ovo vaccination provided 93.25% protection against challenge with a very virulent strain of MD virus (strain RB1/B); by comparison, the conventional vaccination method provided 89.58% protection.
AuthorsG Sarma, W Greer, R P Gildersleeve, D L Murray, A M Miles
JournalAvian diseases (Avian Dis) 1995 Apr-Jun Vol. 39 Issue 2 Pg. 211-7 ISSN: 0005-2086 [Print] UNITED STATES
PMID7677641 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Viral Vaccines
  • Animals
  • Body Weight
  • Chick Embryo
  • Chickens (growth & development)
  • Drug Administration Schedule
  • Energy Metabolism
  • Marek Disease (prevention & control)
  • Safety
  • Vaccination (methods, veterinary)
  • Viral Vaccines (administration & dosage, adverse effects)

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