Abstract |
Acute immobilization stress induced by taping four limbs, applying tail pinch stress and electric foot shock stress immediately reduced the frequency of head shakes induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((+/-)DOI), a 5-HT2A/C agonist in rats. Immobilization stress due to the use of cylinder restraint and forced swimming did not affect 5-HT2A-mediated behavior. Acute immobilization stress did not affect [3H] ketanserin binding to the 5HT2A receptor in the prefrontal cortex and hippocampus. Presynaptic serotonergic lesions with 5,7-dihydroxytryptamine(5,7-DHT) did not affect the reduction in 5-HT2A-mediated behavior after acute immobilization stress. The decreases in head shake frequency after acute immobilization stress by taping were attenuated by pretreatment with diazepam (2.5 mg/kg IP): This attenuation was reversed by pretreatment with flumazenil (10 mg/kg IP). The reduction in (+/-)DOI-induced 5-HT2A-mediated behavior caused by stress may be related to a change in agonist affinity to the receptor or changes in other neurotransmitter systems or the effect of PI turnover.
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Authors | S Yamada, A Watanabe, M Nankai, M Toru |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 119
Issue 1
Pg. 9-14
(May 1995)
ISSN: 0033-3158 [Print] Germany |
PMID | 7675955
(Publication Type: Journal Article)
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Chemical References |
- Serotonin Receptor Agonists
- Diazepam
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Topics |
- Animals
- Diazepam
(pharmacology)
- Dose-Response Relationship, Drug
- Head
(physiology)
- Immobilization
- Male
- Motor Activity
- Rats
- Rats, Wistar
- Serotonin Receptor Agonists
(pharmacology)
- Stress, Physiological
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