Reduction of adhesion reformation after laparoscopic endometriosis surgery: a randomized trial with an oxidized regenerated cellulose absorbable barrier.

Abstract

OBJECTIVE:

To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformation after laparoscopic surgery for endometriosis.

METHODS:

Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed.

RESULTS:

Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05).

CONCLUSION:

The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformation after laparoscopic surgery for endometriosis.

• Authors: V Mais, S Ajossa, D Marongiu, R F Peiretti, S Guerriero, G B Melis
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 86 Issue 4 Pt 1 Pg. 512-5 (Oct 1995) ISSN: 0029-7844 [Print] United States
• PMID: 7675371 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Cellulose, Oxidized
• INTERCEED

Topics

• Adult
• Cellulose, Oxidized (therapeutic use)
• Endometriosis (surgery)
• Female
• Genital Diseases, Female (etiology, prevention & control)
• Humans
• Laparoscopy (adverse effects)
• Recurrence
• Reoperation
• Single-Blind Method
• Tissue Adhesions (etiology, prevention & control)