The case of a 23 years old woman, affected by the
Cohen syndrome, who underwent
general anesthesia for extensive dental surgery, is reported. The
Cohen syndrome is an autosomal recessive syndrome that causes
mental retardation,
obesity, short stature as well as oral, ocular, and limb anomalies. The problems the anesthesiologist could deal with include the capacity of the patient to cooperate; difficult intubation because of maxillary hypoplasia,
micrognathia, narrow and high-arched palate, and prominent maxillary central incisors; generalized
muscular hypotonia; moderate
leukopenia, that could theoretically increase the risk of
infection: and, finally, possible associated
mitral valve prolapse or
hiatus hernia. In the case reported the presence of
mitral valve prolapse or
hiatus hernia was ruled out echographically. The patient was premedicated with
diazepam and
atropine i.m.;
general anesthesia was carried out by
propofol-
fentanyl association and myorelaxation was obtained with
atracurium. Nasotracheal intubation was performed easily in spite of oral anomalies so that the usefulness of thyromental distance, which was 7 cm long, as a clinical test to evaluate a potentially difficult intubation was confirmed. Noteworthy, the thyromental distance was the only test which was suitable for the uncooperative patient. At the end of surgery muscular tone recovered promptly and the endotracheal tube could be regularly removed. No complication was registered postoperatively.