Abstract |
Plasma concentrations of febantel and its major metabolites, fenbendazole, oxfendazole and fenbendazole sulphone, were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection with 100,000 L3 larvae of a benzimidazole (BZ)-sensitive or BZ-resistant strain of Ostertagia circumcincta or with 75,000 L3 larvae of a BZ-sensitive Trichostrongylus colubriformis strain. The febantel concentrations were always low, and in only a few samples were higher than the limit of detection. A mean decrease in the area under the curve (AUC) for the three metabolites of 10.2%, 16.4% and 4.9% in lambs infected, respectively, with BZ-sensitive O. circumcincta, BZ-resistant O. circumcincta and T. colubriformis was observed. The Cmax for all the metabolites was higher in the BZ-sensitive O. circumcincta group than in the naive sheep, while the Tmax occurred earlier. The Cmax and the Tmax values for all the metabolites were lower in the BZ-resistant O. circumcincta group than in their own naive controls. In the T. colubriformis group the Cmax values of the metabolites were lower and the Tmax occurred much later.
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Authors | J Landuyt, M Debackere, J Vercruysse, Q McKellar |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 18
Issue 3
Pg. 180-6
(Jun 1995)
ISSN: 0140-7783 [Print] England |
PMID | 7674453
(Publication Type: Journal Article)
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Chemical References |
- Anthelmintics
- Benzimidazoles
- Guanidines
- Pepsinogens
- Fenbendazole
- oxfendazole
- febantel
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Topics |
- Administration, Oral
- Animals
- Anthelmintics
(pharmacokinetics)
- Benzimidazoles
(blood, pharmacology)
- Drug Resistance
- Feces
(parasitology)
- Fenbendazole
(analogs & derivatives, blood)
- Guanidines
(pharmacokinetics)
- Male
- Ostertagia
(drug effects)
- Ostertagiasis
(drug therapy, metabolism, parasitology, veterinary)
- Parasite Egg Count
(veterinary)
- Pepsinogens
(blood)
- Sheep
- Sheep Diseases
(drug therapy, metabolism, parasitology)
- Trichostrongylosis
(drug therapy, metabolism, parasitology, veterinary)
- Trichostrongylus
(drug effects)
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