Abstract | OBJECTIVES: DESIGN: Prospective case-control study. SETTING: Tertiary-care reproductive medicine center. SUBJECTS: INTERVENTIONS:
Urofollitropin (low-dose, 75 IU; conventional dose, 150 IU) was administered IM daily. Therapy was monitored by serum E2 and vaginal sonography. Hormone determinations were performed by immunoassay. MAIN OUTCOME MEASURES: RESULTS: On the day of hCG administration, patients treated with low-dose therapy exhibited significantly higher ratios of A to E2 (3.5 +/- 0.5 versus 2.2 +/- 0.3 [mean +/- SEM]) and T to E2 (1.5 +/- 0.3 versus 1.0 +/- 0.1) compared with conventional urofollitropin therapy. The number of follicles > or = 16 mm in diameter was significantly lower with low-dose therapy (2.7 +/- 0.6 versus 5.4 +/- 0.4). CONCLUSIONS: Although low-dose therapy was associated with a reduction in the number of recruited follicles, the increase in androgen to E2 associated with this therapy may adversely affect oocyte quality and may explain the relatively high miscarriage rate reported in PCOS patients with this therapy.
|
Authors | R G Brzyski, D R Grow, J A Sims, H J Seltman |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 64
Issue 4
Pg. 693-7
(Oct 1995)
ISSN: 0015-0282 [Print] United States |
PMID | 7672136
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Androgens
- Estrogens
- Follicle Stimulating Hormone
|
Topics |
- Adult
- Androgens
(blood)
- Case-Control Studies
- Dose-Response Relationship, Drug
- Estrogens
(blood)
- Female
- Follicle Stimulating Hormone
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Ovarian Follicle
(drug effects, physiology)
- Polycystic Ovary Syndrome
(blood, drug therapy)
- Prospective Studies
|