HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

GM-CSF-induced acute eosinophilic pneumonia.

Abstract
There is increasing evidence that haemopoietic growth factors are effective in reversal of neutropenia associated with large granular lymphocytes (LGLs) proliferation. A 19-year-old woman with CD3+/TCR gamma delta+, CD4-, CD8- LGL proliferation and severe neutropenia repeatedly developed blood eosinophilia, fever and dyspnoea after administration of GM-CSF. Acute eosinophilic pneumonia with a lobar lung infiltrate pleural effusion, and marked bronchoalveolar lavage fluid eosinophilia was diagnosed. Treatment with corticosteroids and discontinuation of GM-CSF lead to rapid improvement. In addition, haematological analysis revealed that H*1 Technicon, a widely-used automated cell counter, may misinterpret eosinophils erroneously as neutrophils, therefore examination of blood smears to prevent eosinophil-mediated toxicity during GM-CSF treatment is recommended.
AuthorsJ Seebach, R Speich, J Fehr, P Tuchschmid, E Russi
JournalBritish journal of haematology (Br J Haematol) Vol. 90 Issue 4 Pg. 963-5 (Aug 1995) ISSN: 0007-1048 [Print] England
PMID7669682 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Granulocyte-Macrophage Colony-Stimulating Factor
Topics
  • Acute Disease
  • Adult
  • Female
  • Granulocyte-Macrophage Colony-Stimulating Factor (adverse effects)
  • Humans
  • Leukocyte Count
  • Lymphocytes (pathology)
  • Pulmonary Eosinophilia (etiology, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: