Abstract |
There is increasing evidence that haemopoietic growth factors are effective in reversal of neutropenia associated with large granular lymphocytes (LGLs) proliferation. A 19-year-old woman with CD3+/ TCR gamma delta+, CD4-, CD8- LGL proliferation and severe neutropenia repeatedly developed blood eosinophilia, fever and dyspnoea after administration of GM-CSF. Acute eosinophilic pneumonia with a lobar lung infiltrate pleural effusion, and marked bronchoalveolar lavage fluid eosinophilia was diagnosed. Treatment with corticosteroids and discontinuation of GM-CSF lead to rapid improvement. In addition, haematological analysis revealed that H*1 Technicon, a widely-used automated cell counter, may misinterpret eosinophils erroneously as neutrophils, therefore examination of blood smears to prevent eosinophil-mediated toxicity during GM-CSF treatment is recommended.
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Authors | J Seebach, R Speich, J Fehr, P Tuchschmid, E Russi |
Journal | British journal of haematology
(Br J Haematol)
Vol. 90
Issue 4
Pg. 963-5
(Aug 1995)
ISSN: 0007-1048 [Print] England |
PMID | 7669682
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Granulocyte-Macrophage Colony-Stimulating Factor
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Topics |
- Acute Disease
- Adult
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(adverse effects)
- Humans
- Leukocyte Count
- Lymphocytes
(pathology)
- Pulmonary Eosinophilia
(etiology, pathology)
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