Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata.

Abstract

We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.

• Authors: M Hara, M Hunayama, S Aiba, T Suetake, M Watanabe, M Tanaka, H Tagami
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 133 Issue 1 Pg. 121-4 (Jul 1995) ISSN: 0007-0963 [Print] England
• PMID: 7669622 (Publication Type: Case Reports, Journal Article)

Topics

• Alopecia Areata (etiology)
• Carcinoma, Squamous Cell (complications)
• Humans
• Leg
• Male
• Middle Aged
• Paraneoplastic Syndromes (etiology, pathology)
• Skin Diseases (etiology, pathology)
• Skin Neoplasms (complications)
• Vitiligo (etiology)