Abstract |
We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.
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Authors | M Hara, M Hunayama, S Aiba, T Suetake, M Watanabe, M Tanaka, H Tagami |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 133
Issue 1
Pg. 121-4
(Jul 1995)
ISSN: 0007-0963 [Print] England |
PMID | 7669622
(Publication Type: Case Reports, Journal Article)
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Topics |
- Alopecia Areata
(etiology)
- Carcinoma, Squamous Cell
(complications)
- Humans
- Leg
- Male
- Middle Aged
- Paraneoplastic Syndromes
(etiology, pathology)
- Skin Diseases
(etiology, pathology)
- Skin Neoplasms
(complications)
- Vitiligo
(etiology)
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