Methyl-p-hydroxyphenyllactate-esterase activity and type-II estrogen-binding sites in ovarian cancer: correlation with biological and clinico-pathological parameters.
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| Abstract |
We examined the levels of activity of methyl-p-hydroxyphenyllactate esterase (MeHPLA-ase) and cytosolic Type-II-estrogen-binding sites (Type-II EBS) in 61 and 71 cases, respectively, of primary ovarian cancer. MeHPLA-ase activity and Type-II EBS were seen to by asymmetrically distributed, in that levels were skewed towards the lower values. A statistically significant direct correlation was found between MeHPLA-ase activity and Type-II EBS. MeHPLA-ase activity and Type-II EBS were inversely correlated with ER and PR levels and showed a trend towards inverse correlation with the percentage of cells in S-phase of the cell cycle. MeHPLA-ase activity and Type-II EBS did not correlate with clinico-pathological parameters. The median MeHPLA-ase activity tended to be higher in responders than in unresponsive patients, but statistical significance was not reached. Higher Type-II-EBS levels were found in cases showing complete and partial response to chemotherapy than in cases which did not respond. A statistically significant relationship was found between high MeHPLA-ase activity and longer overall survival.
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| Authors | F O Ranelletti, G Scambia, P Benedetti Panici, M Piantelli, G Ferrandina, G D'Agostino, R De Vincenzo, A Rinelli, G Isola, S Mancuso |
| Journal | International journal of cancer (Int J Cancer) Vol. 62 Issue 5 Pg. 536-41 (Sep 04 1995) ISSN: 0020-7136 [Print] United States |
| PMID | 7665223 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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