Abstract |
The oral use of the drug Piavit (derived from freeze-dried medicinal leeches) in 50 patients with coronary heart disease for 7 days in a daily dose of 600 mg (20 patients) and 1200 mg (30 patients) caused a moderate dose-independent increase in enzymatic, fibrinolysis, non-enzymatic fibrinolysis and antithrombin III activity. In half the patients who had low fibrinolytic levels, the agent stimulated mainly the release of plasminogen activator on administration days of 2 and 7. In other 15 patients the activity of plasminogen activator remained unchanged, but non-enzymatic fibrinolysis enhanced. Piavit prolonged the hypocoagulative effect of heparin and aspirin in the group of patients pretreated with these drugs. There were no clinical manifestations of the disease during 7 days.
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Authors | V M Panchenko, T N Serebriakova, L V Podorol'skaia, S M Sorokoletov, P Kh Dzhanashiia |
Journal | Eksperimental'naia i klinicheskaia farmakologiia
(Eksp Klin Farmakol)
1995 May-Jun
Vol. 58
Issue 3
Pg. 28-31
ISSN: 0869-2092 [Print] Russia (Federation) |
Vernacular Title | Vliianie piiavita na protsessy gemostaza, fibrinoliza u bol'nykh ishemicheskoĭ bolezn'iu serdtsa. |
PMID | 7663290
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Biological Factors
- Capsules
- Fibrinolytic Agents
- piyavit
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Topics |
- Aged
- Animals
- Biological Factors
(administration & dosage, pharmacology)
- Capsules
- Chronic Disease
- Drug Evaluation
- Drug Interactions
- Female
- Fibrinolysis
(drug effects)
- Fibrinolytic Agents
(administration & dosage, pharmacology)
- Hemostasis
(drug effects)
- Humans
- Leeches
- Male
- Middle Aged
- Myocardial Ischemia
(blood, drug therapy)
- Saliva
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