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[The effect of piyavit on hemostatic processes and fibrinolysis in patients with ischemic heart disease].

Abstract
The oral use of the drug Piavit (derived from freeze-dried medicinal leeches) in 50 patients with coronary heart disease for 7 days in a daily dose of 600 mg (20 patients) and 1200 mg (30 patients) caused a moderate dose-independent increase in enzymatic, fibrinolysis, non-enzymatic fibrinolysis and antithrombin III activity. In half the patients who had low fibrinolytic levels, the agent stimulated mainly the release of plasminogen activator on administration days of 2 and 7. In other 15 patients the activity of plasminogen activator remained unchanged, but non-enzymatic fibrinolysis enhanced. Piavit prolonged the hypocoagulative effect of heparin and aspirin in the group of patients pretreated with these drugs. There were no clinical manifestations of the disease during 7 days.
AuthorsV M Panchenko, T N Serebriakova, L V Podorol'skaia, S M Sorokoletov, P Kh Dzhanashiia
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 May-Jun Vol. 58 Issue 3 Pg. 28-31 ISSN: 0869-2092 [Print] Russia (Federation)
Vernacular TitleVliianie piiavita na protsessy gemostaza, fibrinoliza u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.
PMID7663290 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Biological Factors
  • Capsules
  • Fibrinolytic Agents
  • piyavit
Topics
  • Aged
  • Animals
  • Biological Factors (administration & dosage, pharmacology)
  • Capsules
  • Chronic Disease
  • Drug Evaluation
  • Drug Interactions
  • Female
  • Fibrinolysis (drug effects)
  • Fibrinolytic Agents (administration & dosage, pharmacology)
  • Hemostasis (drug effects)
  • Humans
  • Leeches
  • Male
  • Middle Aged
  • Myocardial Ischemia (blood, drug therapy)
  • Saliva

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