[The effects of mexidol in pain syndromes].

Abstract

Models of neuropathic pain syndrome and adjuvant arthritis were used to study the effect of mexidole, an antioxidant from the 3-hydroxypyridine group. Mexidole was indicated to produce no preventive effect in pain syndromes, but to exhibit a therapeutic one. The use of mexidole in combination with the agents activating the monoaminergic systems in the central nervous system showed the presence of their reciprocal effect in neuropathic pain syndrome and its absence in adjuvant arthritis. Possible mechanisms of action of mexidole were also discussed.

• Authors: E D Danilova, V N Grafova, T A Voronina, V K Reshetniak
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 May-Jun Vol. 58 Issue 3 Pg. 17-20 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Effekty meksidola pri bolevykh sindromakh.
• PMID: 7663286 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Picolines
• emoxypine succinate

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Arthritis, Experimental (drug therapy)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Interactions
• Drug Therapy, Combination
• Hot Temperature (adverse effects)
• Pain (drug therapy)
• Pain Threshold (drug effects)
• Picolines (pharmacology, therapeutic use)
• Rats
• Syndrome
• Time Factors