Abstract | OBJECTIVE: CASE SUMMARY: A 20-year old man was treated for an osteosarcoma with a chemotherapy regimen that included ifosfamide, methotrexate, and doxorubicin. Three months after completing therapy he developed polyuria, polydypsia, and bilateral ankle pain. Laboratory findings showed decreased serum concentrations of phosphorus, uric acid, calcium potassium, and bicarbonate; elevated blood urea nitrogen and creatinine; and increased urinary excretion of phosphorus, potassium, calcium, citrate, and protein. The patient was diagnosed with Fanconi syndrome and osteomalacia. Treatment with oral supplements of potassium, sodium, citric acid, calcium, and calcitriol corrected the electrolyte abnormalities. DISCUSSION: CONCLUSIONS: The development of renal tubular defects and renal failure should be considered in patients receiving ifosfamide. Although this complication appears more frequently in children, adults also can be affected. Renal function should be monitored closely to detect the appearance of this adverse effect. Renal tubular dysfunction can, as this case illustrates, develop months after completing chemotherapy.
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Authors | A A Garcia |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 29
Issue 6
Pg. 590-1
(Jun 1995)
ISSN: 1060-0280 [Print] United States |
PMID | 7663031
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Bone Neoplasms
(complications, drug therapy)
- Fanconi Syndrome
(chemically induced, complications)
- Humans
- Ifosfamide
(adverse effects)
- Male
- Osteomalacia
(complications)
- Osteosarcoma
(complications, drug therapy)
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