Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family.

Abstract

Tumor suppressor genes represent a broad class of genes that normally function in the negative regulation of cell proliferation. Loss-of-function mutations in these genes lead to unrestrained cell proliferation and tumor formation. A fundamental understanding of how tumor suppressor genes regulate cell proliferation and differentiation should reveal important aspects of signalling pathways and cell cycle control. A recent report describing the Drosophila tumor suppressor gene warts has implications in the study of the human myotonic dystrophy gene. These genes encode members of a cyclic AMP-dependent protein kinase subfamily that includes other plant and animal orthologues.

• Authors: K L Watson
• Journal: BioEssays : news and reviews in molecular, cellular and developmental biology (Bioessays) Vol. 17 Issue 8 Pg. 673-6 (Aug 1995) ISSN: 0265-9247 [Print] United States
• PMID: 7661848 (Publication Type: Journal Article, Review)

Chemical References

• DMPK protein, human
• Drosophila Proteins
• Protein Kinases
• LATS1 protein, human
• wts protein, Drosophila
• Myotonin-Protein Kinase
• Protein Serine-Threonine Kinases

Topics

• Animals
• Drosophila (genetics, metabolism)
• Drosophila Proteins
• Genes, Tumor Suppressor (genetics)
• Humans
• Myotonin-Protein Kinase
• Protein Kinases
• Protein Serine-Threonine Kinases (classification, genetics)