Pharmacokinetics of 4-[4"-(2",2",6",6"-tetramethyl-1"-piperidinyloxy) amino]-4'-demethylepipodophyllotoxin in mice bearing sarcoma 180.

Abstract

AIM:

To study the pharmacokinetics of 4-[4"-(2",2",6",6"-tetramethyl- 1"-piperindyloxy) amino]-4'-demethylepipodophyllotoxin (GP-7) in mice bearing sarcoma 180.

METHOD:

Using HPLC with a uv detector at 285 nm.

RESULTS:

The plasma concentration-time course of GP-7 in mice was best fitted to a 2-compartment open modle after iv 20, 60 mg.kg-1. At both doses the plasma T1/2 beta was around 40 min. The highest concentration was found in liver and lung. The level of GP-7 was higher in tumor than in kidney, spleen, and bone marrow after ip 20 mg.kg-1 for 10 d. Urinary excretion of GP-7 as unchanged drug accounted for about 20% of the administered doses 72 h after injection.

CONCLUSION:

GP-7 disappeared more slowly from the plasma of mice bearing sarcoma 180, distributed extensively over the tissues and was partially excreted from urine. The concentrition of GP-7 in tumor was higher.

• Authors: Z P Jia, J W Xie, T Q Xie
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 16 Issue 3 Pg. 197-200 (May 1995) ISSN: 0253-9756 [Print] China
• PMID: 7660809 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• GP 7
• Podophyllotoxin

Topics

• Animals
• Antineoplastic Agents (pharmacokinetics, urine)
• Female
• Liver (metabolism)
• Lung (metabolism)
• Male
• Mice
• Neoplasm Transplantation
• Podophyllotoxin (analogs & derivatives, pharmacokinetics, urine)
• Sarcoma 180 (metabolism)
• Tissue Distribution