Abstract |
Hypothermia or a glutamate receptor antagonist may offer protection when used before or within seconds of an ischemic insult. In this experiment, we tested the efficacy of hypothermia (34 degrees C) versus CGS-19755 (a potent competitive N-methyl-D-aspartate ( NMDA) receptor blocker) and their combination which was administered 0.5 h after a 5-min forebrain ischemic insult in gerbils. Morphological assessments were done in Group A at the end of 7 days while Group B was evaluated at 29 days. Each group had four sets of animals: saline treated controls; hypothermia treated; CGS-19755 treated; and a combination of CGS-19755 + hypothermia treated animals. Group A showed significant 'protection', i.e. minimal neuronal damage in the animals treated with hypothermia alone. Protection was evident in the cerebral cortex (P < 0.001), hippocampus CA1 (P < 0.01), and in the striatum (P < 0.05). There was no evidence of neuronal protection in the animals that had received either CGS-19755 alone or a combination of hypothermia and CGS-19755. In Group B (29 day assessment) the neuroprotective effects were not evident in any of the animals when compared to the controls. Behavioral testing with Morris water-maze testing showed no significant differences between the control and any of the treated animals. Our data suggests that 'post-ischemic' therapy with hypothermia may delay the effects of ischemia but does not offer significant long-term neuronal protection. Protection seen at 7 days is not evident at 29 days.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | A Shuaib, T Waqar, T Wishart, R Kanthan |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 191
Issue 1-2
Pg. 87-90
(May 19 1995)
ISSN: 0304-3940 [Print] Ireland |
PMID | 7659298
(Publication Type: Journal Article)
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Chemical References |
- Pipecolic Acids
- selfotel
- N-Methylaspartate
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Topics |
- Animals
- Brain Ischemia
(drug therapy, pathology, therapy)
- Combined Modality Therapy
- Gerbillinae
- Hypothermia, Induced
- Injections, Intraperitoneal
- Male
- Maze Learning
(drug effects)
- N-Methylaspartate
(antagonists & inhibitors)
- Pipecolic Acids
(administration & dosage, therapeutic use)
- Prosencephalon
(blood supply, pathology)
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