[Effects of prostacyclin MM-706 on liver function restoration in dogs after severe hemorrhagic shock].

Abstract

The new synthetic analogue of prostaglandin I2 (prostacyclin MM-706) influence on some hepatic function indexes was studied up in 7 dogs with an acute hepatic insufficiency caused by severe hemorrhagic shock. Rapid and steady normalization of indexes and the animals survival were promoted by intravenous infusion of MM-706 given in 300 ng/kg dose together with hemocorrector named lactoprotein given in 10 ml/kg dose (7,5 +/- 1,4) hours later. Possible action mechanisms of the MM-706 therapeutic efficacy are considered. Results of investigation performed constitute an experimental base of the MM-706 application in the complex treatment of an acute hepatic insufficiency of different genesis in the clinic.

• Authors: M P Pavlovskiĭ, O M Oborin, Iu E Lille, M I Lopp, R M Zubachik
• Journal: Klinicheskaia khirurgiia (Klin Khir (1962)) Issue 11 Pg. 60-2 ( 1994) Ukraine
• Vernacular Title: Vplyv prostatsyklinu MM-706 na vidnovlennia funktsiĭ pechinky u sobak pislia tiazhkoho hemorahichnoho shoku.
• PMID: 7658666 (Publication Type: English Abstract, Journal Article)

Chemical References

• Epoprostenol

Topics

• Animals
• Dogs
• Epoprostenol (analogs & derivatives, pharmacology, therapeutic use)
• Female
• Liver (drug effects, physiopathology)
• Liver Failure, Acute (drug therapy, etiology, physiopathology)
• Liver Function Tests
• Male
• Shock, Hemorrhagic (drug therapy, physiopathology)