Abstract | BACKGROUND & AIMS: METHODS: RESULTS: Compared with vehicle, CGP 47969A (10 mg/kg) significantly reduced the acute inflammatory index by 58%, edema by 67%, necrosis by 99%, and myeloperoxidase activity by 49% (all P < 0.02) with efficacy similar to that of steroids. These effects were associated with a significant inhibition of colonic IL-1 alpha and IL-8 by 56% and 90%, respectively (p < 0.01). CONCLUSIONS:
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Authors | V Casini-Raggi, L Monsacchi, K Vosbeck, C C Nast, T T Pizarro, F Cominelli |
Journal | Gastroenterology
(Gastroenterology)
Vol. 109
Issue 3
Pg. 812-8
(Sep 1995)
ISSN: 0016-5085 [Print] United States |
PMID | 7657109
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- CGP 47969A
- Cytokines
- Interleukin-1
- Interleukin-8
- Piperazines
- Peroxidase
- Hydrocortisone
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Colitis
(drug therapy, immunology, metabolism)
- Colon
(enzymology, metabolism, pathology)
- Cytokines
(antagonists & inhibitors, biosynthesis)
- Hydrocortisone
(therapeutic use)
- Immune Complex Diseases
(drug therapy, immunology, metabolism)
- Interleukin-1
(antagonists & inhibitors, biosynthesis)
- Interleukin-8
(antagonists & inhibitors, biosynthesis)
- Male
- Peroxidase
(metabolism)
- Piperazines
(therapeutic use)
- Rabbits
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