[Antitumor activities of 8-chloroadenosine in vivo and in vitro].

Abstract

8-chloroadenosine showed marked activity against mice solid tumor hepatoma 22 (H22) and ascitic leukemia L-1210. At 100mg. Kg-1. /d x 7, the inhibition rate of H22 was 71.7 +/- 13.3% (P < 0.01) and 66.1 +/- 4.46% (P < 0.01), i.p. and i.v., respectively; at the same dose, the life-prolonging rate of mice bearing L-1210 was 124.0 +/- 22.1% (P < 0.01) and 104.2 +/- 20.1% (P < 0.01), i.p. and i.v., respectively. 8-chloroadenosine also showed activity against 3 human cancer cell lines in vitro. The IC50 values were determined by measuring cell growth using trypan blue dye exclusion. The results showed that HL-60 and K562, and human gastric cancer cell line MGc80-3 and IC50 values of 1. 8 mumol/L, 4.2 mumol/L and 1.56 mumol/L, respectively. The toxicity of 8-chloroadenosine was low, with LD50 of 1025.0 +/- 52.4 mg/kg for mice and 793.4 +/- 70.1 mg/kg for rats by single i.p. injection.

• Authors: J Fang, Y Shi, L Zhang
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 17 Issue 1 Pg. 5-8 (Jan 1995) ISSN: 0253-3766 [Print] China
• PMID: 7656789 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• 2-Chloroadenosine
• 8-chloroadenosine

Topics

• 2-Chloroadenosine (analogs & derivatives, pharmacology, therapeutic use, toxicity)
• Animals
• Antineoplastic Agents (pharmacology, therapeutic use, toxicity)
• Female
• Lethal Dose 50
• Leukemia L1210 (drug therapy, pathology)
• Liver Neoplasms, Experimental (drug therapy, pathology)
• Male
• Mice
• Mice, Inbred DBA
• Neoplasm Transplantation
• Rats
• Rats, Wistar
• Stomach Neoplasms (pathology)
• Tumor Cells, Cultured (drug effects)