[The antitumor activities of gnidimacrin isolated from Stellera chamaejasme L].

Abstract

Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera chamaejasme L, showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo. At the dosages of 0.02-0.03mg/kg ip, the in increase in life span (ILS) was 70% and 80%, respectively. Gnidimacrin was also active against murine solid tumors in vivo, such as Lewis lung carcinoma, B-16 melanoma and colon cancer 26. It showed ILSs of 40%, 49% and 41% at the dosages of 0.01-0.02mg/kg ip, respectively. Gnidimacrin strongly inhibited cell proliferation of human cancer cell lines such as leukemia K562, stomach cancers Kato-III, MKN-28, MKN-45, and mouse L-1210 by the MTT assay and colony forming assay in vitro. The IC50 of gnidimacrin was 0.007-0.00012microgram/ml. It is concluded that gnidimacrin is the principal antitumor element in Stellera chamaejasme L. with strong antitumor activities.

• Authors: W Feng, I Tetsuro, Y Mitsuzi
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 17 Issue 1 Pg. 24-6 (Jan 1995) ISSN: 0253-3766 [Print] China
• PMID: 7656781 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• gnidimacrin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Carcinoma, Lewis Lung (drug therapy)
• Diterpenes (pharmacology, therapeutic use)
• Female
• Leukemia, Experimental (drug therapy)
• Melanoma, Experimental (drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Tumor Cells, Cultured (drug effects)