Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.

Abstract

A total of 112 species of edible plants (122 samples) from Thailand were randomly collected, and their methanol extracts were screened for in vitro anti-tumor promoting activity using the inhibition test of Epstein-Barr virus (EBV) activation in Raji cells induced by 12-O-hexadecanoylphorbol-13-acetate (HPA, 40 ng/ml). It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml. Significantly, the ratio is markedly higher than that (26%) previously observed in common edible plants in Japan. Thus, physiological potentiality of edible Thai plants has been implied in terms of cancer chemoprevention.

• Authors: A Murakami, S Jiwajinda, K Koshimizu, H Ohigashi
• Journal: Cancer letters (Cancer Lett) Vol. 95 Issue 1-2 Pg. 139-46 (Aug 16 1995) ISSN: 0304-3835 [Print] Ireland
• PMID: 7656222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents

Topics

• Anticarcinogenic Agents (chemistry)
• Herpesvirus 4, Human
• Humans
• In Vitro Techniques
• Mutagenicity Tests
• Plants, Edible (chemistry)
• Plants, Medicinal (chemistry)
• Thailand
• Virus Replication (drug effects)