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Efficacy of diltiazem in recurrent supraventricular tachyarrhythmias.

Abstract
Diltiazem alters human atrioventricular nodal properties in a dose and rate-dependent manner. Intravenous diltiazem is effective in converting supraventricular tachycardia to sinus rhythm. It may be a very useful drug for sustained control of heart rate in patients with rapid atrial fibrillation. The recommended intravenous dose is 0.25 mg/kg given over 2 mins followed by a maintenance infusion of 5 to 15 mg/h. Clinical data on the electrophysiological effects of oral diltiazem are limited. The oral form may be used as an alternative agent for the prophylaxis of recurrent supraventricular tachycardia.
AuthorsD Roy
JournalThe Canadian journal of cardiology (Can J Cardiol) 1995 Jul-Aug Vol. 11 Issue 7 Pg. 538-40 ISSN: 0828-282X [Print] England
PMID7656189 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Verapamil
  • Diltiazem
Topics
  • Administration, Oral
  • Diltiazem (administration & dosage)
  • Dose-Response Relationship, Drug
  • Humans
  • Injections, Intravenous
  • Recurrence
  • Retrospective Studies
  • Tachycardia, Supraventricular (drug therapy, prevention & control)
  • Verapamil (administration & dosage)

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