Pamidronate treatment of the neurologic sequelae of pagetic spinal stenosis.

Abstract

Spinal stenosis is a serious complication of Paget's disease of bone. Surgical decompression has a high complication rate and is not always effective. Medical therapy with bisphosphonates is established treatment in other forms of Paget's disease. To our knowledge, this is the first report of the use of intravenous pamidronate disodium as the sole treatment of lower limb weakness attributable to pagetic spinal stenosis. Our patient has been restored to independent living and has maintained his remission, with repeated treatment, for more than 5 years.

• Authors: E Wallace, J Wong, I R Reid
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 155 Issue 16 Pg. 1813-5 (Sep 11 1995) ISSN: 0003-9926 [Print] United States
• PMID: 7654117 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphonates
• Pamidronate

Topics

• Aged
• Aged, 80 and over
• Diphosphonates (therapeutic use)
• Humans
• Male
• Osteitis Deformans (complications)
• Pamidronate
• Peripheral Nervous System Diseases (drug therapy, etiology)
• Spinal Stenosis (complications, etiology)