Analysis of the relationship between hemoglobin-oxygen affinity and lipid peroxidation during fever.

Abstract

Endogenous hyperthermia was induced in rabbits by i.v. pyrogenal administration. Hemoglobin-oxygen affinity and parameters of free radical lipid oxidation in plasma and red blood cells were measured. The content of diene conjugates, malonic dialdehyde and Schiff bases were determined at a pyrogenal dose of 4 minimal pyrogenic doses/kg, and iron-initiated chemiluminescence, catalase activity and alpha-tocopherol concentration were determined at 6 minimal pyrogenic doses/kg. A rightward shift of the real oxyhemoglobin dissociation curve and activation of lipid peroxidation were observed. Relationships between the parameters measured were analyzed. Decreased hemoglobin-oxygen affinity is considered to be a possible mechanism of activation of free radicals during fever.

• Authors: M V Borisiuk, V V Zinchuk
• Journal: Acta biochimica Polonica (Acta Biochim Pol) Vol. 42 Issue 1 Pg. 69-74 ( 1995) ISSN: 0001-527X [Print] Poland
• PMID: 7653164 (Publication Type: Journal Article)

Chemical References

• Ferrous Compounds
• Free Radicals
• Lipopolysaccharides
• Oxyhemoglobins
• Pyrogens
• Schiff Bases
• pyrogenal
• Vitamin E
• ferrous sulfate
• Malondialdehyde
• Catalase

Topics

• Animals
• Body Temperature
• Catalase (metabolism)
• Erythrocytes (enzymology, metabolism)
• Ferrous Compounds (chemistry)
• Fever (metabolism)
• Free Radicals (metabolism)
• Lipid Peroxidation
• Lipopolysaccharides
• Malondialdehyde (blood)
• Oxyhemoglobins (metabolism, physiology)
• Pyrogens
• Rabbits
• Schiff Bases (blood)
• Time Factors
• Vitamin E (blood, metabolism)