Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids.

Abstract

Stavaroside K, veratramine and cevine induce hemolysis, whereas 7 other pregnane stavarosides and 8 Veratrum alkaloids are not hemolytic. On the other hand, erythrocytes pretreated or incubated with low concentrations of stavarosides D-F or with the 8 other Veratrum alkaloids were resistant to hemolysis induced by authentic saponin, stavaroside K, cevine or veratramine. Veratridine, zygadenine and angeloylzygadenine (the known Na-Channel-Gate toxins) revealed the most potent reduction of hemolytic activity.

• Authors: F A Badria, J D McChesney, A F Halim, A M Zaghloul, K A el Sayed
• Journal: Die Pharmazie (Pharmazie) Vol. 50 Issue 6 Pg. 421-3 (Jun 1995) ISSN: 0031-7144 [Print] Germany
• PMID: 7651981 (Publication Type: Journal Article)

Chemical References

• Cevanes
• Glucosides
• Pregnanes
• Saponins
• Veratrum Alkaloids
• stavaroside K
• cevine
• veratramine

Topics

• Cevanes (antagonists & inhibitors, pharmacology)
• Erythrocytes (drug effects)
• Glucosides (antagonists & inhibitors, pharmacology)
• Hemolysis (drug effects)
• Humans
• In Vitro Techniques
• Pregnanes (pharmacology)
• Saponins (pharmacology)
• Veratrum Alkaloids (antagonists & inhibitors, pharmacology)