Inhibition of macrophage procoagulant activity with lipids reduces intra-abdominal abscess formation in mice.

Abstract

Macrophage procoagulant activity (PCA) has been proposed as a critical element in the formation of intra-abdominal abscesses. We tested the ability of local and systemic lipids (a known PCA inhibitor in vitro) to alter both peritoneal macrophage PCA and mixed Escherichia coli/Bacteroides fragilis intra-abdominal abscess formation in vivo. Lipids given intraperitoneally inhibited measured inducible peritoneal macrophage PCA for 8 h, and, in other animals, significantly decreased the number of abscesses formed and prevented abscesses in 29% of animals. Parallel experiments using subcutaneous intralipids did not show these effects. These results support the hypothesis that macrophage PCA produced locally is critical for intraperitoneal abscess formation.

• Authors: R G Sawyer, T L Pruett
• Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes (Eur Surg Res) Vol. 27 Issue 4 Pg. 222-6 ( 1995) ISSN: 0014-312X [Print] Switzerland
• PMID: 7649208 (Publication Type: Journal Article)

Chemical References

• Blood Coagulation Factors
• Lipids
• macrophage procoagulant activity

Topics

• Abdomen
• Abscess (prevention & control)
• Animals
• Blood Coagulation Factors (antagonists & inhibitors)
• Infusions, Parenteral
• Injections, Subcutaneous
• Lipids (administration & dosage, pharmacology)
• Macrophages (metabolism)
• Male
• Mice
• Mice, Inbred BALB C