Abstract |
Neurogenic oedema formation in the rat hind paw skin induced by electrical stimulation of the saphenous nerve and measured by extravasation of [125I]- albumin, was inhibited by the 5-HT1B receptor agonist, CP-93,129, and the novel tryptamine analogue, CP-122,288. Significant inhibition of up to 66% of control was observed with CP-122,288 (2 x 10(-14) - 2 x 10(-7) mol kg-1) and CP-93,129 (5 x 10(-7) - 5 x 10(-6) mol kg-1), with the minimum effective dose for CP-122,288 being about 10(7) fold less than that for CP-93,129. Oedema formation induced by the intradermal administration of exogenous mediators ( substance P and histamine) in rat dorsal skin was not inhibited by CP-122,288 (2 x 10(-10) mol kg-1). These results suggest that CP-122,288 is a potent inhibitor of neurogenic inflammation in rat skin and that the effect may be due to a prejunctional inhibition of neuropeptide release.
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Authors | R Kajekar, P Gupta, N B Shepperson, S D Brain |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 115
Issue 1
Pg. 1-2
(May 1995)
ISSN: 0007-1188 [Print] England |
PMID | 7647962
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pyridines
- Pyrroles
- Pyrrolidines
- Serotonin Receptor Agonists
- 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one
- CP 122288
- Sumatriptan
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Topics |
- Analysis of Variance
- Animals
- Edema
(prevention & control)
- Electric Stimulation
- Male
- Neuritis
(prevention & control)
- Neurons, Afferent
(drug effects)
- Pyridines
(pharmacology)
- Pyrroles
(pharmacology)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Wistar
- Serotonin Receptor Agonists
(pharmacology)
- Sumatriptan
(analogs & derivatives, pharmacology)
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