[Influence of splenectomy on drug therapy for acute liver failure induced by D-galactosamine and lipopolysaccharide in rats].

Abstract

We studied protective effects of dibutyryl cyclic AMP (DBcAMP 15 mg/kg i.p.) and OK-432 (5 KE/body), and the role of the spleen on D-galactosamine (D-Gal 500 mg/kg i.p.) and lipopolysaccharide (endotoxin: Et 0.5 mg/kg i.p.) induced acute liver failure. The survival rates were 10% in the control group (D-Gal+Et), 53% in the group I A (DBcAMP was administered at 1 hour before D-Gal administration), 79% in the group I B (Splenectomy was performed at 24 hours before D-Gal administration on the group I A), 87% in the group II A (OK-432 was administered at 24 hours before D-Gal administration), and 64% in the group II B (Splenectomy was performed at 24 hours before D-Gal administration on the group II A). GOT activities and TNF activities were significantly improved in the treatment groups, and in the group I B and group II A, they were more improved than in the group I A and group II B. In conclusion, spleen had the positive effect for OK-432 treatment, and also had the negative effect for DBcAMP treatment on acute liver failure induced by D-Gal and Et.

• Authors: K Kudo, A Kakisaka, S Kasai, M Mito
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 92 Issue 7 Pg. 1051-7 (Jul 1995) ISSN: 0446-6586 [Print] Japan
• PMID: 7643459 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lipopolysaccharides
• Picibanil
• Bucladesine
• Galactosamine

Topics

• Animals
• Bucladesine (therapeutic use)
• Galactosamine
• Lipopolysaccharides
• Liver Failure, Acute (chemically induced, drug therapy)
• Male
• Picibanil (therapeutic use)
• Rats
• Rats, Wistar
• Spleen (physiology)
• Splenectomy