Histopathological and histoenzimological investigations of the rheumatoid articular cartilage.

Abstract

Twenty seven biopsies of articular cartilage taken intraoperatively from patients with Rheumatoid arthritis (RA) and from control patients with traumas were examined using histopathological techniques (HE, VG, PAS-Alcian, Gömöri, Safranine 0) and histoenzymological techniques (Acid phosphatase-lysomal marker, Chondroitinsulphatase, Peroxidase). Histopathologically, the rheumatoid articular cartilage appears with superficial and deep cartilaginous fissures, frequent perichondrocytic gaps associated with modification of the tinctorial activity. At the pannus synovia-cartilage junction we found invasive and destructive synovial inflammatory infiltrates penetrating and eroding the cartilage. Histoenzymologically, the rheumatoid chondrocytes have a high lysosomal potential (phosphatasic, chondroitinsulphatasic) and highly oxidative potential (peroxidasic) specific for lesion modifications.

• Authors: A Ciobanu, I R Ciobanu, F Hălălău, D Laky, I Dinulescu, D Stănculescu, M Stoicescu, I Stroescu
• Journal: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Rom J Morphol Embryol) 1994 Jan-Jun Vol. 40 Issue 1-2 Pg. 23-7 ISSN: 1220-0522 [Print] Romania
• PMID: 7640371 (Publication Type: Journal Article)

Chemical References

• Peroxidase
• Acid Phosphatase
• Chondroitinsulfatases

Topics

• Acid Phosphatase (analysis)
• Arthritis, Rheumatoid (pathology)
• Cartilage, Articular (enzymology, pathology)
• Chondroitinsulfatases (analysis)
• Histocytochemistry
• Humans
• Lysosomes (enzymology)
• Microscopy, Electron
• Peroxidase (analysis)