Comparative study of the dialysability of iobitridol and iohexol in the rat with impaired renal function.

Abstract

PURPOSE:

To assess the dialysability of iobitridol, a comparative study with iohexol was conducted in the rat over 4 hours.

MATERIAL AND METHODS:

After ligature of the renal veins and arteries, a group of animals was submitted to continuous peritoneal dialysis, while the remainder were not.

RESULTS:

In the event of total renal failure, biliary excretion rose from 0.4 to 9% for iobitridol and from 2 to 16% for iohexol. In the rats submitted to peritoneal dialysis, biliary excretion decreased to 5% in the iobitridol group and to 13% in the iohexol group. Further, 18% of the test substances were eliminated in the dialysis liquid.

CONCLUSIONS:

As their physicochemical characteristics are very similar, the differences between the biliary excretion levels of these 2 media may be caused by a factor related to their respective molecular conformations.

• Authors: A Dencausse, C Chambon, X Violas, B Bonnemain
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 36 Issue 5 Pg. 545-8 (Sep 1995) ISSN: 0284-1851 [Print] England
• PMID: 7640101 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• iobitridol
• Iohexol

Topics

• Animals
• Biliary Tract (metabolism)
• Contrast Media
• Evaluation Studies as Topic
• Iohexol (analogs & derivatives, pharmacokinetics)
• Male
• Peritoneal Dialysis
• Rats
• Rats, Sprague-Dawley
• Renal Insufficiency (metabolism)