[Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice].

Abstract

In the present experiments, an impairment of memory model was made by cerebral ischemia-reperefusion in mice. Sal A at the dosage of 3 and 10 mg.kg-1 i.v. was shown to improve the impairment of memory function induced by cerebral ischemia-reperefusion in step down and step through tests. In these tests, the number of errors of Sal A treated group was less and the latency was longer than that of control group. Meanwhile, Sal A 3 and 10 mg.kg-1 i.v. was found to reduce the MDA contents in the cortex, hippocampus and striatum of cerebral ischemia-reperfused rats in vivo. Sal A 10-100 nmol.L-1 was shown to inhibit the brain lipid-peroxidation and scavenge the free hydroxyl radical in vitro. These results indicate that the antagonistic effects of Sal A on impairment of learning and memory caused by cerebral ischemia-reperefusion may be related with its anti-oxidant activity.

• Authors: G H Du, J T Zhang
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 30 Issue 3 Pg. 184-90 ( 1995) ISSN: 0513-4870 [Print] China
• PMID: 7639081 (Publication Type: Journal Article)

Chemical References

• Caffeic Acids
• Drugs, Chinese Herbal
• Free Radical Scavengers
• Lactates
• salvianolic acid A

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (complications)
• Caffeic Acids (therapeutic use)
• Drugs, Chinese Herbal (therapeutic use)
• Free Radical Scavengers (pharmacology)
• Lactates (therapeutic use)
• Male
• Memory Disorders (etiology, prevention & control)
• Mice
• Rats
• Reperfusion Injury (complications, metabolism)