Abstract | BACKGROUND:
Endotoxin ( lipopolysaccharide [LPS]) stimulation of tissue-fixed macrophages induces the generation of toxic oxidants. However, recent studies also implicate redox changes in both the signal transduction pathways for cytokine genes and the generation of physiologically active arachidonic acid metabolites. Because cytokines and arachidonic acid metabolites initiate and perpetuate deleterious systemic inflammatory responses, we tested whether macrophage activation could be modulated by antioxidants. METHODS: RESULTS: CONCLUSIONS:
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Authors | C Mendez, I Garcia, R V Maier |
Journal | Surgery
(Surgery)
Vol. 118
Issue 2
Pg. 412-20
(Aug 1995)
ISSN: 0039-6060 [Print] United States |
PMID | 7638759
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antioxidants
- Blood Coagulation Factors
- Endotoxins
- Tumor Necrosis Factor-alpha
- macrophage procoagulant activity
- Vitamin E
- Dinoprostone
- Acetylcysteine
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Topics |
- Acetylcysteine
(pharmacology)
- Animals
- Antioxidants
(pharmacology)
- Blood Coagulation Factors
(metabolism)
- Dinoprostone
(biosynthesis)
- Endotoxins
(pharmacology)
- Macrophages, Alveolar
(drug effects, physiology)
- Male
- Rabbits
- Tumor Necrosis Factor-alpha
(biosynthesis)
- Vitamin E
(pharmacology)
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