Evaluation of the anticancer property of a new alpha-methylene-gamma-lactone derivative of phthalimide.

Abstract

The anticancer property of a new alpha-methylene-gamma-lactone derivative of phthalimide (2, NSC 640168) was evaluated in two murine ascitic tumors namely Ehrlich ascites carcinoma (EAC) and sarcoma-180 (S-180) by in vivo screenings and in a battery of human tumor cell lines by in vitro screening. It was found that the compound has exhibited marginal to moderate in vivo activity in EAC and S-180, respectively, and significant in vitro cytotoxicity in SF-268, a human CNS tumor cell line. The compound, however, has not reached the criteria of significant anti-HIV activity.

• Authors: U Sanyal, S Dutta, H Das
• Journal: Neoplasma (Neoplasma) Vol. 42 Issue 3 Pg. 129-32 ( 1995) ISSN: 0028-2685 [Print] Slovakia
• PMID: 7637822 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• NSC 640168
• Phthalimides

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Carcinoma, Ehrlich Tumor (drug therapy)
• Cell Survival (drug effects)
• Central Nervous System Neoplasms (drug therapy)
• Drug Screening Assays, Antitumor
• Humans
• Male
• Mice
• Phthalimides (pharmacology)
• Sarcoma 180 (drug therapy)
• Tumor Cells, Cultured (drug effects)