HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis.

AbstractPURPOSE:
We study the prevalence of human papillomavirus deoxyribonucleic acid (DNA) in squamous cell carcinoma and control tissue of the penis.
MATERIALS AND METHODS:
The technique of polymerase chain reaction DNA amplification was used to detect specific human papillomavirus DNA sequences in archival pathological and control tissues. We analyzed 42 cases of invasive squamous cell carcinoma, 13 of carcinoma in situ, 12 of penile intraepithelial neoplasia, 3 of verrucous carcinoma and 25 of balanitis xerotica obliterans, as well as 29 routine neonatal circumcision specimens and 32 adult circumcision specimens.
RESULTS:
Overall, the detection rates for human papillomavirus DNA in the study and control tissues were 55% (23 of 42 cases) for invasive squamous cell carcinoma, 92% (12 of 13) for carcinoma in situ, 92% (11 of 12) for penile intraepithelial neoplasia, 0% (0 of 3) for verrucous carcinoma, 4% (1 of 25) for balanitis xerotica obliterans, 0% (0 of 29) for neonatal circumcision and 9% (3 of 32) for adult circumcision. In all groups human papillomavirus type 16 was the most common genotype identified.
CONCLUSIONS:
The prevalence of human papillomavirus DNA is significantly greater in carcinoma of the penis than in control tissue. Moreover, the prevalence is greater in noninvasive lesions (carcinoma in situ and penile intraepithelial neoplasia) than in invasive carcinoma.
AuthorsM R Cupp, R S Malek, J R Goellner, T F Smith, M J Espy
JournalThe Journal of urology (J Urol) Vol. 154 Issue 3 Pg. 1024-9 (Sep 1995) ISSN: 0022-5347 [Print] United States
PMID7637047 (Publication Type: Journal Article, Review)
Chemical References
  • DNA, Viral
Topics
  • Balanitis (metabolism)
  • Base Sequence
  • Carcinoma in Situ (chemistry)
  • Carcinoma, Squamous Cell (chemistry)
  • Carcinoma, Verrucous (chemistry)
  • Circumcision, Male
  • DNA, Viral (analysis)
  • Humans
  • Infant, Newborn
  • Lymphatic Metastasis
  • Male
  • Molecular Sequence Data
  • Papillomaviridae (genetics)
  • Penile Neoplasms (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: