Abstract | BACKGROUND: METHODS: RESULTS:
SCH 434 QD was consistently superior to placebo in controlling the symptoms of seasonal allergic rhinitis. Composite symptom scores (total, total nasal, and total nonnasal) were reduced significantly in patients treated with SCH 434 QD as compared with placebo (p < 0.01). When compared with its individual components, reductions in mean symptom scores were consistently greater, numerically, in patients treated with SCH 434 QD than in patients who were treated with either loratadine or pseudoephedrine alone. SCH 434 QD was superior to pseudoephedrine in reducing nonnasal symptoms at all time points (p < 0.01), and superior to loratadine in relieving nasal stuffiness at end point (p < 0.01). In the physicians' evaluation of therapeutic response, the SCH 434 QD group had the greatest number of patients with a good or excellent response at end point (58%). All treatments were generally well tolerated with no serious or unusual adverse events. Insomnia and nervousness, adverse events commonly associated with pseudoephedrine, were noted in a significantly greater number of patients treated with SCH 434 QD or pseudoephedrine (p < or = 0.04) as compared with those treated with loratadine or placebo. CONCLUSIONS: The results of the study demonstrate that SCH 434 QD is more effective than placebo or either of its components alone in the treatment of seasonal allergic rhinitis.
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Authors | E Bronsky, P Boggs, S Findlay, S Gawchik, J Georgitis, H Mansmann, L Sholler, J Wolfe, E Meltzer, R Morris |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 96
Issue 2
Pg. 139-47
(Aug 1995)
ISSN: 0091-6749 [Print] United States |
PMID | 7636050
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Double-Blind Method
- Drug Therapy, Combination
- Ephedrine
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Loratadine
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Rhinitis, Allergic, Seasonal
(drug therapy)
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