Plasmalogen oxidation in human serum lipoproteins.

Abstract

The content of plasmalogens in lipoproteins--very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL)--in human serum was determined and compared with that after oxidation of the lipoproteins. Similarly, the content of alpha-hydroxyaldehydes produced from plasmalogens via their epoxids during lipidperoxidation (LPO) was studied. Incubation with Fe+ +/ascorbate results in a dramatic decrease in plasmalogens that correlates with an appropriate increase in alpha-hydroxyaldehydes. VLDL and LDL plasmalogens were oxidized to a greater extend (99% decrease) compared to HDL plasmalogens (35%). This finding is discussed with respect to atherogenesis and the recently postulated protective qualities of plasmalogens.

• Authors: R Felde, G Spiteller
• Journal: Chemistry and physics of lipids (Chem Phys Lipids) Vol. 76 Issue 2 Pg. 259-67 (Jun 19 1995) ISSN: 0009-3084 [Print] Ireland
• PMID: 7634364 (Publication Type: Journal Article)

Chemical References

• Aldehydes
• Epoxy Compounds
• Lipoproteins
• Lipoproteins, HDL
• Lipoproteins, LDL
• Lipoproteins, VLDL
• Peroxides
• Plasmalogens
• Ascorbic Acid

Topics

• Aldehydes (analysis, chemistry)
• Ascorbic Acid (chemistry, pharmacology)
• Epoxy Compounds (chemistry)
• Humans
• Lipid Peroxidation
• Lipoproteins (blood, chemistry)
• Lipoproteins, HDL (blood, chemistry)
• Lipoproteins, LDL (blood, chemistry)
• Lipoproteins, VLDL (blood, chemistry)
• Mass Spectrometry
• Oxidation-Reduction
• Peroxides (chemistry, pharmacology)
• Plasmalogens (blood, chemistry)