Somatostatin receptor expression in the thyroid demonstrated with 111In-octreotide scintigraphy.

Abstract

Neuroendocrine tumors with somatostatin receptor expression may be localized by 111In-octreotide scintigraphy. This study examines those thyroid conditions where 111In-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111In-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland 14 patients with 111In thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves' disease. Thus, 111In-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.

• Authors: W Becker, U Schrell, M Buchfelder, J Hensen, J Wendler, M Gramatzki, F Wolf
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 34 Issue 3 Pg. 100-3 (Jun 1995) ISSN: 0029-5566 [Print] Germany
• PMID: 7630741 (Publication Type: Case Reports, Journal Article)

Chemical References

• Indium Radioisotopes
• Receptors, Somatostatin
• indium-111-octreotide
• Triiodothyronine
• Thyrotropin
• Thyroxine
• Octreotide

Topics

• Adult
• Gene Expression
• Goiter, Endemic (diagnostic imaging, metabolism)
• Humans
• Indium Radioisotopes
• Male
• Octreotide (analogs & derivatives, metabolism)
• Radionuclide Imaging
• Receptors, Somatostatin (analysis, biosynthesis)
• Thyroid Diseases (diagnostic imaging, metabolism)
• Thyroid Gland (diagnostic imaging, metabolism)
• Thyroid Neoplasms (diagnostic imaging, metabolism)
• Thyrotropin (blood)
• Thyroxine (blood)
• Triiodothyronine (blood)
• Ultrasonography